Programmed longevity, youthspan, and juventology – lifespans and Healthspan

Volter Longo has some interesting new ideas regarding how we look at life expectancy, lifespan. He recommends thinking about spans in terms of youthspan (peak health 20-60) and Healthspan (oriented to disease free stage and the older phase (65-120).

check – Longo VD. Programmed longevity, youthspan, and juventology. Aging Cell. 2019;18:e12843. https://doi.org/10.1111/acel.12843 

also check David Sinclair’s new book Lifespan: Why We Age―and Why We Don’t Have To — is a really great book! Highly recommended …. packed with information … some should be taken with a grain of salt or maybe with a Sirtuin activator like NMN 🙂

 

 

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Nutrition Science Journals -per Google Scholar

OK, so last week I ran a search on Google Scholar to identify the top Nutrition Sciences Journals and publications:

Listed in terms of Rank –  Publication – this is what it showed.

1 The American Journal of Clinical Nutrition

2 Nutrients

3 Critical Reviews in Food Science and Nutrition

4 British Journal of Nutrition

5 Clinical Nutrition

6 The Journal of Nutrition

7 Advances in Nutrition

8 Journal of Functional Foods

9 Journal of the Academy of Nutrition and Dietetics

10 Molecular Nutrition & Food Research

11 Nutrition

12 Public Health Nutrition

13 Nutrition Reviews

14 European Journal of Nutrition

15 The Journal of Nutritional Biochemistry

16 Journal of Parenteral and Enteral Nutrition

17 Current Opinion in Clinical Nutrition & Metabolic Care

18 European Journal of Clinical Nutrition

19 Nutrition Journal

20 Proceedings of the Nutrition Society

 

The top papers in AJCN with Title/Citation Count/Year of Publication:

Vitamin D deficiency in Europe: pandemic?  /397/ 2016
KD Cashman, KG Dowling, Z Škrab.kov., M Gonzalez-Gross, J Valtue.a, .
The American Journal of Clinical Nutrition 103 (4), 1033-1044
A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. /377/  2014
JS Lai, S Hiles, A Bisquera, AJ Hure, M McEvoy, J Attia
The American journal of clinical nutrition 99 (1), 181-197
Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC) / 302 / 2015
U Ekelund, HA Ward, T Norat, J Luan, AM May, E Weiderpass, SJ Sharp, 
The American Journal of Clinical Nutrition 101 (3), 613-621

 

Dietary sugars and cardiometabolic risk: systematic review and
meta-analyses of randomized controlled trials of the effects on blood pressure and lipids /289 / 2014 -LA Te Morenga, 
AJ Howatson, RM Jones, J Mann The American Journal of Clinical Nutrition 100 (1), 65-79

Lower protein content in infant formula reduces BMI and 
obesity risk at school age: follow-up of a randomized trial /
283 /2014 - M Weber, V Grote, R Closa-Monasterolo, J Escribano, JP Langhendries, ...The American Journal of Clinical Nutrition 99 (5), 1041-1051
Myofibrillar muscle protein synthesis rates subsequent to a meal inresponse to increasing doses of whey protein at rest and afterresistance exercise./281 /2014
OC Witard, SR Jackman, L Breen, K Smith, A Selby, KD Tipton
The American journal of clinical nutrition 99 (1), 86-95



WHY AM I DOING THIS?

I am doing this because nutrition, diet, and exercise are
thing we can actually control.  If we educate ourselves and.  the next generation, we have a much better chance at a higher quality of life for a longer duration, and also less expensive government.  The way things are, health care costs are  
skyrocketing.  If we get healthier, costs will go down, taxes will fall, and we'll all be happier all around!

Parabiosis, Reprogramming, and Diet

Live longer … think “Epigenetic Diet”.

Pay attention to “The Aging Epigenome” – paper by Lauren  Booth  and Anne Brunet (over at the  Glenn Laboratories for the Biology of Aging, Stanford U).

also pay attention to Brian J. Morris, Bradley J. Willcox, Timothy A. Donlon , Genetic and epigenetic regulation of human aging and longevity. Bbadis (2018), doi:10.1016/ j.bbadis.2018.08.039

Get familiar with Sirtuins,   resveratrol,   spermidine,  metformin, selenium,  learn to enjoy  green tea, broccoli sprouts and soybean products.

OK … exercise definitely helps!

 

 

 

 

 

Want to avoid lung cancer?

Listen. … Just don’t smoke to start with … No one can guarantee what happens … but, if you smoke you triple your risk over people who never smoked …

Framingham Heart Study researchers find that former smokers who quit smoking 25 or more years ago still have three times as much risk of developing lung cancer compared to people who have never smoked.

from the Framingham Heart Study highlights

Carotenoids Database provides information on 1182 natural carotenoids 

The Carotenoids Database looks pretty cool!

According to the site it “currently provides information on 1182 natural carotenoids  in 700 source organisms..

Check it out here 

A recent review paper,  [Rodriguez-Concepcion, M., Avalos, J., Bonet, M. L., Boronat, A., Gomez-Gomez, L., Hornero-Mendez, D., … & Ribot, J. (2018). A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. Progress in lipid research, 70, 62-93.]

states

Carotenoids are isoprenoid metabolites synthesized by all photosynthetic organisms (including plants, algae and cyanobacteria) and some non-photosynthetic archaea, bacteria, fungi and animals. In photosynthetic systems, carotenoids participate in light harvesting and they are essential for photoprotection

 

[AND]

In addition, carotenoids can be cleaved to produce compounds with roles as growth regulators, such as abscisic acid (ABA) and strigolactones, as well as bioactive molecules. Most animals (including humans) do not synthesize carotenoids de novo but take them in the diet and use them as essential precursors for the production of retinoids such as vitamin A. Additionally; carotenoids have been proposed to confer other health benefits whose discovery is spurring their use in functional food products.

 

This needs to be included in the Artificial Intelligence for Medicine Initiative

Bats are the longest-lived mammals for their size

I didn’t know that 🙂 apparently others do … cool!

Only 19 species of mammal are longer-lived than humans given their body size, and 18 of these species are bats

check this paper out.  [Foley, Nicole M., Graham M. Hughes, Zixia Huang, Michael Clarke, David Jebb, Conor V. Whelan, Eric J. Petit et al. “Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity.” Science advances 4, no. 2 (2018): eaao0926.]

 

 

artificial intelligence, natural stupidity.

according to popular legends and urban myths … Amos Tversky is said to have said …

My colleagues, they study artificial intelligence; me, I study natural stupidity.

this, from CoEvolving Innovations which seems like a fascinating resource.

The blog entry there talks about Daniel Kahneman  and Amos Tversky.

The topic is fascinating.  The question of how intelligence and stupidity are related is fascinating.

There’s also a reference to Daniel Kahneman, Paul Slovic, and Amos Tversky book Judgment under uncertainty: Heuristics and biases,  that I now feel compelled to investigate

interesting factoid …Kahneman  was awarded the 2002 Nobel Prize in economic sciences  despite being a psychologist, not an economist.  Which goes to show you … that Forrest Gump’s Mom was right  Life is like a box of chocolates. You never know what you’re gonna get.”