Programmed longevity, youthspan, and juventology – lifespans and Healthspan

Volter Longo has some interesting new ideas regarding how we look at life expectancy, lifespan. He recommends thinking about spans in terms of youthspan (peak health 20-60) and Healthspan (oriented to disease free stage and the older phase (65-120).

check – Longo VD. Programmed longevity, youthspan, and juventology. Aging Cell. 2019;18:e12843. https://doi.org/10.1111/acel.12843 

also check David Sinclair’s new book Lifespan: Why We Age―and Why We Don’t Have To — is a really great book! Highly recommended …. packed with information … some should be taken with a grain of salt or maybe with a Sirtuin activator like NMN 🙂

 

 

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Hagen’s Biological and clinical data integration in healthcare study is great!

Just finished looking at Matt Hagen’s 2014 “Biological and clinical data integration and its applications in healthcare.” PhD  dissertation. This is a great piece of work … You can find it here.

While its around 5 years old, the insights and discussion are excellent.  I like the detailed breakdown of how different ontologies and vocabularies align (and how things fall through the cracks).  I liked the discussion of using Neo4j to analyze relationships and simplify searches and relationship mappings.

Particularly liked the discussion of using  ontologies.  to” facilitate improved prioritization of intensive care admissions and accurate clustering of multimorbidity conditions”.  THIS IS BIG! with enormous potential.

Discussion of his BioSPIDA relational database translator and its contrast with  the separate Entrez Gene, Pubmed, CDD, Refseq, MMDB, and Biosystems NCBI databases.

His Table 7.2: Descriptions of patient clusters is rather illuminating, as his discussion and analysis of ICU Electronic Health Records and findings associated with morbidity outcomes.

For example Cluster 1 contains the following Most Prevalent Conditions: Coronary arteriosclerosis, Hypercholesterolemia, Diabetes, Gastroesophageal reflux disease,  Atrial fibrillation, Hyperlipidemia, Tobacco dependence.  Which led to the following Most Prevalent Procedures:  Catheterization of left heart, Cardiopulmonary bypass operation, Angiocardiography of left heart,.

 

 I  am surprised this work is not cited as much as it should be!.  IMHO, this work definitely should be used as blueprint for additional investigations.

 

 

Experiment 2 -The Search for Deep Learning Impact

Now added a recent search that looked for recent USPTO grants that specified Deep Learning and Medicine …

filed under

PATEX 2: Patent Exploration for Artificial Intelligence in Medicine (AIM)

Experiment 2 -The Search for Deep Learning Impact

As an amusing element, it picked up this:

US-10040551-B2. – Drone delivery of coffee based on a cognitive state of an individual.

enjoy!